SHOC2

Across TCGA patient cohorts, SHOC2 mutation is significantly associated with the RNA expression of many other genes, with 3,784 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHOC2-associated genes across cancer lineages are RN7SKP43, RN7SKP14, and RNA5SP328. Each is linked with SHOC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHOC2-to-partner and partner-to-SHOC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP43 grouped by SHOC2-low versus SHOC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOC2→partner) and Y-score (partner→SHOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP43 →	+0.196	+5.412	<.001	.001	3	3
SKCM	RN7SKP14 →	+0.068	+4.993	<.001	.002	3	2
HNSC	RNA5SP328 →	+0.136	+4.178	<.001	.007	3	2
UCEC	NUDT4P2 →	+0.029	+2.106	<.001	.007	3	2
UCEC	MRM3 →	+0.527	+4.269	<.001	<.001	3	2
BRCA	MIR4462 →	+0.524	+5.045	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,784 associations by consensus.

RN7SKP43 by SHOC2 expression — COAD

Explore this box plot interactively →