SHMT2

Across TCGA patient cohorts, SHMT2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,057 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SHMT2-associated proteins across cancer lineages are NCAPD2, NCAPG, and PA2G4. Each is linked with SHMT2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SHMT2-to-partner and partner-to-SHMT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHMT2 versus NCAPD2 in BRCA, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT2→partner) and Y-score (partner→SHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCAPD2 →	+0.693	+0.620	<.001	<.001	3	8
UCEC	NCAPG →	+0.566	+1.301	<.001	<.001	3	8
OV	PA2G4 →	+0.283	+0.522	<.001	<.001	3	8
LSCC	KDM3A →	+0.587	+0.866	<.001	<.001	3	8
LUAD	MKI67 →	+0.705	+0.575	<.001	<.001	3	8
LUAD	ECT2_T359 →	+1.133	+0.623	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,057 associations by consensus.

SHMT2 vs NCAPD2 — BRCA

Explore this scatter interactively →