SHMT2

Across TCGA patient cohorts, SHMT2 mutation is significantly associated with the RNA expression of many other genes, with 922 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHMT2-associated genes across cancer lineages are RNU6-1289P, LINC00458, and MIR6853. Each is linked with SHMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT2-to-partner and partner-to-SHMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1289P grouped by SHMT2-low versus SHMT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT2→partner) and Y-score (partner→SHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1289P →	+0.377	+4.867	<.001	.005	3	2
UCEC	LINC00458 →	+0.454	+2.161	<.001	.007	3	2
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
STAD	RNU4-17P →	+0.206	+4.485	<.001	.007	3	1
STAD	RNU6-1001P →	+0.157	+4.485	.006	.007	3	1
STAD	GPM6BP1 →	+0.154	+5.506	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 922 associations by consensus.

RNU6-1289P by SHMT2 expression — SKCM

Explore this box plot interactively →