SHMT2

Across TCGA patient cohorts, SHMT2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHMT2-associated genes across cancer lineages are JNK2, Shc_pY317, and ASNS. Each is linked with SHMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT2-to-partner and partner-to-SHMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SHMT2-low versus SHMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT2→partner) and Y-score (partner→SHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.315	+2.817	.006	.036	3	1
UCEC	Shc_pY317 →	-0.299	-3.000	<.001	.036	3	1
UCEC	ASNS →	+0.537	+3.000	.010	.037	3	1
UCEC	ER-alpha →	-1.101	-3.000	.020	.037	2	1
UCEC	FASN →	+0.449	+3.000	.048	.037	2	1
UCEC	PCNA →	+0.303	+3.000	.015	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK2 by SHMT2 expression — UCEC

Explore this box plot interactively →