SHMT2

Across TCGA cell cohorts, SHMT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,156 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHMT2-associated GO terms across cancer lineages are L-amino acid biosynthetic process, L-serine biosynthetic process, and Alpha-amino acid biosynthetic process. Each is linked with SHMT2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SHMT2-to-partner and partner-to-SHMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-amino acid biosynthetic process grouped by SHMT2-low versus SHMT2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT2→partner) and Y-score (partner→SHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	L-amino acid biosynthetic process →	+0.149	+1.347	<.001	<.001	3	11
BLOOD_Leukemia	L-serine biosynthetic process →	+0.156	+0.791	<.001	<.001	3	11
PANCREAS	Alpha-amino acid biosynthetic process →	+0.135	+1.186	<.001	<.001	3	10
STOMACH	Cell cycle DNA replication initiation →	+0.176	+1.201	.002	.002	3	10
STOMACH	Nuclear cell cycle DNA replication initiation →	+0.176	+1.201	.002	.002	3	10
STOMACH	Mitotic DNA replication initiation →	+0.176	+1.201	.002	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,156 associations by consensus.

L-amino acid biosynthetic process by SHMT2 expression — PANCREAS

Explore this box plot interactively →