SHMT2

Across TCGA cell cohorts, SHMT2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHMT2-associated genes across cancer lineages are KRTAP4-11, KRTAP7-1, and AVP. Each is linked with SHMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT2-to-partner and partner-to-SHMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-11 grouped by SHMT2-low versus SHMT2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT2→partner) and Y-score (partner→SHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP4-11 →	+0.045	+5.209	<.001	.005	3	2
LARGE_INTESTINE	KRTAP7-1 →	+0.034	+3.700	<.001	.009	3	2
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	S100G →	+0.399	+3.095	<.001	.009	3	1
OVARY	TAS2R39 →	+0.019	+3.405	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

KRTAP4-11 by SHMT2 expression — BLOOD_Lymphoma

Explore this box plot interactively →