SHMT1

Across TCGA cell cohorts, SHMT1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHMT1-associated genes across cancer lineages are OR2C1, XCR1, and GAS2L2. Each is linked with SHMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHMT1-to-partner and partner-to-SHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2C1 grouped by SHMT1-low versus SHMT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHMT1→partner) and Y-score (partner→SHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2C1 →	+0.103	+3.725	.002	.008	3	1
LARGE_INTESTINE	XCR1 →	+0.353	+3.491	<.001	.006	3	1
LARGE_INTESTINE	GAS2L2 →	+0.110	+3.807	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR2C1 by SHMT1 expression — LARGE_INTESTINE

Explore this box plot interactively →