SHLD2P2

Across TCGA pan-cancer cohorts, SHLD2P2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SHLD2P2 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SHLD2P2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHLD2P2 expression acts as an unfavorable survival marker, although some lineages such as SARC and SKCM show a favorable association.

UCS, THYM, and CHOL are the cancer types where SHLD2P2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	All	0.174	0.642	<.001	56	view →
THYM	OS	Quartile	II,III,IV	0.586	0.929	.010	20	view →
CHOL	OS	Median	All	0.317	0.764	.009	18	view →
READ	DFS	Tertile	IV	0.315	0.771	.009	15	view →
SARC	DFS	Median	All	0.730	0.541	.004	15	view →
SKCM	OS	Tertile	II,III,IV	0.888	0.807	.017	12	view →
THCA	DFS	Median	All	0.965	0.912	.006	12	view →
LAML	DFS	Median	All	0.503	0.269	.009	12	view →
ESCA	OS	Quartile	III,IV	0.642	0.302	.018	11	view →
STAD	DFS	Tertile	III,IV	0.434	0.635	.020	11	view →
COAD	OS	Tertile	II,III,IV	0.903	0.823	.013	10	view →
TGCT	DFS	Tertile	All	0.913	0.747	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SHLD2P2–UCS (DFS)

Open the UCS breakdown →