SHLD2P2

Across TCGA pan-cancer cohorts, SHLD2P2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SHLD2P2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SHLD2P2 RNA is repressed in tumor relative to normal tissue. In most cancer types SHLD2P2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and STAD are the cancer types where SHLD2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHLD2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.054	<.001	7	view →
THCA	All	All	−0.042	<.001	4	view →
STAD	Male	IV	+0.025	.037	1	view →
HNSC	Male	All	+0.018	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SHLD2P2–KICH

Open the KICH breakdown →