SHLD2P1

Across TCGA patient cohorts, SHLD2P1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHLD2P1-associated genes across cancer lineages are RN7SL248P, RN7SL680P, and MIR4306. Each is linked with SHLD2P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHLD2P1-to-partner and partner-to-SHLD2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SHLD2P1-low versus SHLD2P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD2P1→partner) and Y-score (partner→SHLD2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.285	+6.722	<.001	<.001	3	1
UCEC	RN7SL680P →	+0.404	+5.133	<.001	.008	3	1
UCEC	MIR4306 →	+0.722	+5.081	<.001	.008	3	1
UCEC	MIR4422 →	+0.788	+5.420	<.001	.005	3	1
UCEC	VN1R3 →	+0.157	+4.982	.001	.009	3	1
UCEC	MIR7-2 →	+0.655	+5.621	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

RN7SL248P by SHLD2P1 expression — UCEC

Explore this box plot interactively →