SHLD2

Across TCGA cell cohorts, SHLD2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHLD2-associated genes across cancer lineages are MYL1, OR7D4, and SYCP1. Each is linked with SHLD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHLD2-to-partner and partner-to-SHLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL1 grouped by SHLD2-low versus SHLD2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD2→partner) and Y-score (partner→SHLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MYL1 →	+0.265	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	OR7D4 →	+0.039	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	SYCP1 →	+0.018	+4.350	.007	.005	3	1
BLOOD_Lymphoma	KRTAP5-4 →	+0.022	+4.714	<.001	.002	3	1
LUNG_NSCLC_LUAD	TEX53 →	+0.124	+4.371	<.001	.005	3	1
OVARY	DAZ1 →	+0.102	+4.058	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MYL1 by SHLD2 expression — BLOOD_Lymphoma

Explore this box plot interactively →