SHLD1

Across TCGA patient cohorts, SHLD1 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHLD1-associated genes across cancer lineages are CHEK2P5, MTND6P12, and GYG1P2. Each is linked with SHLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHLD1-to-partner and partner-to-SHLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK2P5 grouped by SHLD1-low versus SHLD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHLD1→partner) and Y-score (partner→SHLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CHEK2P5 →	+0.218	+6.199	<.001	.001	3	1
SKCM	MTND6P12 →	+0.096	+5.224	<.001	.007	3	1
SKCM	GYG1P2 →	+0.084	+5.037	<.001	.009	3	1
UCEC	RPL23AP86 →	+0.255	+4.223	.001	<.001	3	1
SKCM	IGBP1P5 →	+0.073	+5.292	<.001	.006	3	1
UCEC	OR4P4 →	+0.124	+3.771	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

CHEK2P5 by SHLD1 expression — SKCM

Explore this box plot interactively →