SHKBP1

Across TCGA pan-cancer cohorts, SHKBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SHKBP1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SHKBP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SHKBP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where SHKBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	1.000	0.427	.016	4	view →
PDAC	DFS	Median	III,IV	0.325	0.793	.022	4	view →
HNSC	DFS	Tertile	II,III,IV	0.941	1.000	.038	2	view →
CCRCC	DFS	Tertile	II,III,IV	0.767	0.953	.034	2	view →
LSCC	DFS	Median	All	0.896	0.971	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SHKBP1–LUAD (OS)

Open the LUAD breakdown →