SHKBP1

Across TCGA pan-cancer cohorts, SHKBP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SHKBP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SHKBP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SHKBP1 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

HNSC, KIRP, and COAD are the cancer types where SHKBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHKBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.962	<.001	12	view →
KIRP	All	II,III,IV	+0.923	<.001	11	view →
COAD	Female	All	+0.600	<.001	10	view →
LIHC	Female	II,III,IV	+1.576	<.001	9	view →
BLCA	All	All	+1.100	<.001	8	view →
STAD	All	II,III,IV	+1.081	<.001	8	view →
KIRC	All	All	+0.427	<.001	8	view →
BRCA	All	III,IV	+0.991	<.001	6	view →
UCEC	All	II,III,IV	+0.637	.002	6	view →
LUSC	All	All	+0.449	<.001	6	view →
CHOL	Male	All	+2.433	<.001	5	view →
LUAD	All	III,IV	+0.543	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SHKBP1–HNSC

Open the HNSC breakdown →