SHKBP1

Across TCGA patient cohorts, SHKBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,072 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHKBP1-associated genes across cancer lineages are IGSF21-AS1, SKA1, and PBK. Each is linked with SHKBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHKBP1-to-partner and partner-to-SHKBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF21-AS1 grouped by SHKBP1-low versus SHKBP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHKBP1→partner) and Y-score (partner→SHKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGSF21-AS1 →	+0.056	+4.559	<.001	.006	3	3
UCEC	SKA1 →	+0.735	+2.273	<.001	<.001	3	3
UCEC	PBK →	+0.848	+2.273	<.001	<.001	3	3
UCEC	CKAP2L →	+0.532	+2.687	.005	<.001	3	3
UCEC	ESCO2 →	+0.660	+1.938	<.001	.001	3	3
UCEC	TYMS →	+0.805	+2.400	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,072 associations by consensus.

IGSF21-AS1 by SHKBP1 expression — CESC

Explore this box plot interactively →