SHKBP1

Across TCGA patient cohorts, SHKBP1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHKBP1-associated genes across cancer lineages are Rictor, Smad4, and PCNA. Each is linked with SHKBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHKBP1-to-partner and partner-to-SHKBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor grouped by SHKBP1-low versus SHKBP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHKBP1→partner) and Y-score (partner→SHKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rictor →	-0.524	-3.169	.002	.019	3	2
SKCM	Smad4 →	+0.156	+3.169	.010	.019	2	3
UCEC	PCNA →	+0.191	+1.807	.012	.025	3	2
SKCM	Snail →	+0.211	+2.820	.024	.035	3	1
SKCM	B-Raf →	-0.483	-3.169	.014	.019	3	1
SKCM	eEF2K →	-0.428	-3.152	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Rictor by SHKBP1 expression — SKCM

Explore this box plot interactively →