SHKBP1

Across TCGA cell cohorts, SHKBP1 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHKBP1-associated genes across cancer lineages are GPR119, RBMXL3, and KRT77. Each is linked with SHKBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHKBP1-to-partner and partner-to-SHKBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by SHKBP1-low versus SHKBP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHKBP1→partner) and Y-score (partner→SHKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GPR119 →	+0.019	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	RBMXL3 →	+0.008	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	KRT77 →	+0.009	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	OR4M2 →	+0.026	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	SCT →	+0.149	+3.714	<.001	.006	3	1
SKIN	C7orf77 →	+0.066	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

GPR119 by SHKBP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →