SHISAL1

Across TCGA cell cohorts, SHISAL1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SHISAL1-associated genes across cancer lineages are KCNG4, CYP2A13, and BANF2. Each is linked with SHISAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISAL1-to-partner and partner-to-SHISAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNG4 grouped by SHISAL1-low versus SHISAL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISAL1→partner) and Y-score (partner→SHISAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNG4 →	+0.004	+4.539	.009	.007	3	1
BLOOD_Leukemia	CYP2A13 →	+0.010	+5.569	<.001	.001	3	1
CNS	BANF2 →	+0.788	+4.981	<.001	.008	3	1
CNS	TEX55 →	+0.056	+5.321	<.001	.005	3	1
CNS	PRM3 →	+0.175	+5.754	<.001	.002	3	1
BLOOD_Leukemia	IP6K3 →	+0.028	+4.234	.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KCNG4 by SHISAL1 expression — BLOOD_Leukemia

Explore this box plot interactively →