SHISA9

Across TCGA cell cohorts, SHISA9 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHISA9-associated genes across cancer lineages are MUC7, IAPP, and MDGA2. Each is linked with SHISA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA9-to-partner and partner-to-SHISA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC7 grouped by SHISA9-low versus SHISA9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA9→partner) and Y-score (partner→SHISA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MUC7 →	+0.223	+4.152	<.001	.009	3	2
LARGE_INTESTINE	IAPP →	+0.535	+3.906	<.001	.005	3	1
LARGE_INTESTINE	MDGA2 →	+0.129	+3.554	.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.156	+3.725	<.001	.008	3	1
LARGE_INTESTINE	TECRL →	+0.014	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MUC7 by SHISA9 expression — BLOOD_Leukemia

Explore this box plot interactively →