SHISA5

Across TCGA pan-cancer cohorts, SHISA5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SHISA5 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SHISA5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHISA5 expression acts as an unfavorable survival marker.

GBM, HNSC, and LSCC are the cancer types where SHISA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.205	0.518	.002	25	view →
HNSC	DFS	Median	III,IV	0.385	0.883	.008	22	view →
LSCC	DFS	Median	All	0.244	0.890	.006	10	view →
LUAD	DFS	Median	III,IV	0.265	0.899	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SHISA5–GBM (DFS)

Open the GBM breakdown →