SHISA5

Across TCGA pan-cancer cohorts, SHISA5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SHISA5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SHISA5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SHISA5 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where SHISA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHISA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.660	<.001	12	view →
COAD	Male	IV	+1.187	<.001	11	view →
KIRP	Male	II,III,IV	+1.132	<.001	9	view →
LIHC	All	III,IV	+0.955	<.001	9	view →
THCA	Male	All	+0.608	<.001	9	view →
KICH	Female	II,III,IV	−1.222	<.001	8	view →
STAD	Male	II,III,IV	+0.792	<.001	8	view →
BRCA	All	III,IV	+0.644	<.001	6	view →
READ	Female	All	+0.825	<.001	5	view →
HNSC	All	All	+0.552	<.001	4	view →
CHOL	All	All	+0.836	<.001	3	view →
ESCA	All	All	+0.960	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SHISA5–KIRC

Open the KIRC breakdown →