SHISA5

Across TCGA patient cohorts, SHISA5 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA5-associated genes across cancer lineages are NF-kB-p65_pS536, eEF2, and FOXO3a_pS318_S321. Each is linked with SHISA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHISA5-to-partner and partner-to-SHISA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by SHISA5-low versus SHISA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA5→partner) and Y-score (partner→SHISA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.470	-2.999	.012	.035	3	3
UCEC	eEF2 →	+0.430	+2.459	.003	.018	3	2
UCEC	FOXO3a_pS318_S321 →	-0.149	-2.115	.003	.016	3	2
UCEC	GAPDH →	+0.596	+2.459	.007	.018	3	2
UCEC	Annexin-1 →	+0.732	+2.604	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.537	+1.894	.028	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

NF-kB-p65_pS536 by SHISA5 expression — UCEC

Explore this box plot interactively →