SHISA5

Across TCGA cell cohorts, SHISA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,351 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SHISA5-associated GO terms across cancer lineages are Regulation of Wnt protein secretion, Viral process, and Positive regulation of Wnt protein secretion. Each is linked with SHISA5 in more than 10 cancer types. Because this analysis shows association rather than direction, both SHISA5-to-partner and partner-to-SHISA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Wnt protein secretion grouped by SHISA5-low versus SHISA5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA5→partner) and Y-score (partner→SHISA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of Wnt protein secretion →	+0.153	+0.966	<.001	<.001	3	11
STOMACH	Viral process →	+0.103	+0.999	<.001	.003	3	10
BREAST	Positive regulation of Wnt protein secretion →	+0.146	+0.966	<.001	<.001	3	10
BREAST	Regulation of L-glutamate import across plasma membrane →	+0.157	+0.867	<.001	.002	3	10
STOMACH	Negative regulation of complement-dependent cytotoxicity →	+0.161	+0.865	.004	.005	3	9
CNS	Response to interferon-beta →	+0.162	+0.465	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,351 associations by consensus.

Regulation of Wnt protein secretion by SHISA5 expression — BREAST

Explore this box plot interactively →