SHISA5

Across TCGA cell cohorts, SHISA5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHISA5-associated genes across cancer lineages are RBMY1F, CRYGC, and SLC35G3. Each is linked with SHISA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHISA5-to-partner and partner-to-SHISA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1F grouped by SHISA5-low versus SHISA5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA5→partner) and Y-score (partner→SHISA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RBMY1F →	+1.043	+5.643	<.001	.002	3	1
BLOOD_Leukemia	CRYGC →	+0.020	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SLC35G3 →	+0.049	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OR5B2 →	+0.048	+3.774	<.001	.008	3	1
BLOOD_Leukemia	C1QTNF9 →	+0.040	+3.852	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RBMY1F by SHISA5 expression — LUNG_SCLC

Explore this box plot interactively →