Across TCGA patient cohorts, SHISA4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,100 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHISA4-associated genes across cancer lineages are SPOCK1, ELFN2, and PHYHIP. Each is linked with SHISA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SHISA4-to-partner and partner-to-SHISA4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA4→partner) and Y-score (partner→SHISA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPOCK1 →	+3.500	+0.389	.009	.001	3	4
CCRCC	ELFN2 →	+1.250	+0.389	.003	.001	3	3
GBM	PHYHIP →	+0.916	+0.451	<.001	<.001	3	3
GBM	GABRD →	+0.856	+0.438	<.001	<.001	3	3
LSCC	THPO →	+0.700	+0.519	.005	.004	3	3
LSCC	NUDT10 →	+1.463	+0.521	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,100 associations by consensus.

Exploration

SHISA4 survival (RNA) · tumor vs normal (RNA) · all SHISA4 data types