SHISA2

Across TCGA patient cohorts, SHISA2 mutation is significantly associated with the RNA expression of many other genes, with 2,428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHISA2-associated genes across cancer lineages are RNA5SP419, RN7SL248P, and TBC1D3P1. Each is linked with SHISA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHISA2-to-partner and partner-to-SHISA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by SHISA2-low versus SHISA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHISA2→partner) and Y-score (partner→SHISA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP419 →	+0.500	+1.977	<.001	.004	3	3
UCEC	RN7SL248P →	+0.056	+3.059	<.001	.005	3	2
LUAD	TBC1D3P1 →	+0.211	+3.689	.005	.007	3	2
UCEC	RNU6-1 →	+0.349	+2.045	.009	<.001	3	2
UCEC	RNU2-51P →	+0.435	+1.904	<.001	.002	3	2
UCEC	RNA5SP146 →	+0.247	+2.109	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,428 associations by consensus.

RNA5SP419 by SHISA2 expression — UCEC

Explore this box plot interactively →