SHF

Across TCGA pan-cancer cohorts, SHF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SHF data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SHF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SHF expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where SHF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.871	1.000	.015	17	view →
CCRCC	OS	Tertile	III,IV	1.000	0.156	.024	15	view →
GBM	DFS	Quartile	All	0.515	0.276	.007	4	view →
LUAD	DFS	Quartile	III,IV	0.286	0.946	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SHF–LSCC (DFS)

Open the LSCC breakdown →