SHF

Across TCGA pan-cancer cohorts, SHF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SHF’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SHF RNA is repressed in tumor relative to normal tissue. In most cancer types SHF is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, THCA, and BRCA are the cancer types where SHF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.121	<.001	11	view →
THCA	Male	III,IV	+1.067	<.001	10	view →
BRCA	Female	II,III,IV	−0.552	<.001	6	view →
LUAD	Male	II,III,IV	+0.872	<.001	5	view →
COAD	All	All	+0.644	.004	5	view →
UCEC	All	All	−0.993	<.001	4	view →
PRAD	All	All	−0.664	<.001	2	view →
HNSC	All	All	−0.367	.032	2	view →
KICH	All	All	−0.315	.016	2	view →
CHOL	All	All	−1.008	.007	1	view →
LIHC	Female	All	−0.737	.011	1	view →
STAD	All	All	−0.526	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SHF–BLCA

Open the BLCA breakdown →