SHF

Across TCGA patient cohorts, SHF RNA expression is significantly associated with the protein abundance of many other proteins, with 19,071 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHF-associated proteins across cancer lineages are TP53BP1, VCL_S346, and FTSJ3_S584. Each is linked with SHF in more than 5 cancer types. Because this analysis shows association rather than direction, both SHF-to-partner and partner-to-SHF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHF versus TP53BP1 in GBM, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHF→partner) and Y-score (partner→SHF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TP53BP1 →	+0.262	+0.540	<.001	<.001	3	6
UCEC	VCL_S346 →	+0.587	+0.565	<.001	<.001	3	6
BRCA	FTSJ3_S584 →	-0.578	-0.430	<.001	.004	3	6
GBM	HDGFL3 →	+0.503	+0.832	<.001	<.001	3	6
OV	LMNB2 →	+0.318	+0.478	<.001	.001	3	6
UCEC	PRKG1 →	+0.588	+0.442	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,071 associations by consensus.

SHF vs TP53BP1 — GBM

Explore this scatter interactively →