SHF

Across TCGA patient cohorts, SHF protein abundance is significantly associated with the RNA expression of many other genes, with 9,176 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHF-associated genes across cancer lineages are PEAK1, XYLT1, and LTBP2. Each is linked with SHF in more than 4 cancer types. Because this analysis shows association rather than direction, both SHF-to-partner and partner-to-SHF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHF versus PEAK1 in CCRCC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHF→partner) and Y-score (partner→SHF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PEAK1 →	+0.630	+0.630	.007	.004	3	5
GBM	XYLT1 →	+0.924	+0.412	<.001	<.001	3	4
CCRCC	LTBP2 →	+1.722	+0.822	<.001	.002	3	4
CCRCC	CNRIP1 →	+0.998	+0.790	.001	.003	3	4
CCRCC	GLT8D2 →	+0.925	+0.532	.003	.002	2	5
LSCC	PGBD1 →	+0.658	+0.511	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,176 associations by consensus.

SHF vs PEAK1 — CCRCC

Explore this scatter interactively →