SHF

Across TCGA patient cohorts, SHF mutation is significantly associated with the RNA expression of many other genes, with 934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHF-associated genes across cancer lineages are RN7SL83P, RPS28P1, and IL21. Each is linked with SHF in more than 1 cancer types. Because this analysis shows association rather than direction, both SHF-to-partner and partner-to-SHF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL83P grouped by SHF-low versus SHF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHF→partner) and Y-score (partner→SHF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL83P →	+0.324	+4.807	.001	.004	3	2
BLCA	RPS28P1 →	+0.231	+4.914	<.001	<.001	3	2
UCEC	IL21 →	+0.240	+3.348	<.001	<.001	3	2
CESC	MIR410 →	+0.310	+4.757	<.001	.004	3	2
CESC	RNA5SP198 →	+0.218	+4.559	<.001	.006	3	2
BLCA	OR8G2P →	+0.070	+4.996	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 934 associations by consensus.

RN7SL83P by SHF expression — COAD

Explore this box plot interactively →