SHF

Across TCGA patient cohorts, SHF mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHF-associated genes across cancer lineages are VHL, ERK2, and JNK_pT183_Y185. Each is linked with SHF in more than 1 cancer types. Because this analysis shows association rather than direction, both SHF-to-partner and partner-to-SHF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SHF-low versus SHF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHF→partner) and Y-score (partner→SHF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.988	-3.321	.002	.010	3	2
UCEC	ERK2 →	+0.261	+2.459	.004	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.446	.015	.020	3	1
UCEC	MEK1 →	+0.546	+3.169	.001	.019	3	1
UCEC	MSH2 →	-0.453	-3.160	<.001	.019	3	1
UCEC	MSH6 →	-0.530	-2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

VHL by SHF expression — UCEC

Explore this box plot interactively →