SHF

Across TCGA cell cohorts, SHF RNA expression is significantly associated with the go_rna of many other GO terms, with 5,497 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SHF-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Regulation of myoblast fusion, and Positive regulation of DNA repair. Each is linked with SHF in more than 14 cancer types. Because this analysis shows association rather than direction, both SHF-to-partner and partner-to-SHF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by SHF-low versus SHF-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHF→partner) and Y-score (partner→SHF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.059	+1.873	.001	.002	3	15
STOMACH	Regulation of myoblast fusion →	+0.150	+2.019	<.001	.002	3	14
BONE	Positive regulation of DNA repair →	+0.076	+2.278	<.001	<.001	3	14
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.146	+2.341	<.001	<.001	3	14
OESOPHAGUS	Mitochondrial electron transport, cytochrome c to oxygen →	+0.165	+1.696	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.061	+0.703	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,497 associations by consensus.

Epigenetic regulation of gene expression by SHF expression — BONE

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