SHD

Across TCGA patient cohorts, SHD protein abundance is significantly associated with the RNA expression of many other genes, with 11,928 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SHD-associated genes across cancer lineages are SPECC1L, YPEL1, and SNRPD3. Each is linked with SHD in more than 1 cancer types. Because this analysis shows association rather than direction, both SHD-to-partner and partner-to-SHD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHD versus SPECC1L in GBM, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHD→partner) and Y-score (partner→SHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPECC1L →	+0.293	+0.750	.006	.001	3	1
GBM	YPEL1 →	+0.557	+0.573	<.001	<.001	3	1
GBM	SNRPD3 →	+0.440	+0.618	<.001	<.001	3	1
GBM	GGT1 →	+0.160	+0.566	.005	.002	3	1
GBM	ESS2 →	+0.341	+0.900	.004	<.001	3	1
GBM	GRK3 →	+0.633	+0.771	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,928 associations by consensus.

SHD vs SPECC1L — GBM

Explore this scatter interactively →