SHD

Across TCGA patient cohorts, SHD mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHD-associated genes across cancer lineages are FoxM1, Heregulin, and MAPK_pT202_Y204. Each is linked with SHD in more than 1 cancer types. Because this analysis shows association rather than direction, both SHD-to-partner and partner-to-SHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SHD-low versus SHD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHD→partner) and Y-score (partner→SHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.298	+2.817	.021	.036	3	1
UCEC	Heregulin →	-0.152	-3.459	.014	.005	3	1
UCEC	MAPK_pT202_Y204 →	-0.475	-2.321	.044	.035	3	1
UCEC	p27_pT198 →	+0.113	+2.321	.035	.035	3	1
UCEC	Rab11 →	-0.160	-2.321	.028	.035	3	1
UCEC	S6_pS240_S244 →	+0.402	+3.000	.049	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FoxM1 by SHD expression — UCEC

Explore this box plot interactively →