SHD

Across TCGA cell cohorts, SHD RNA expression is significantly associated with the go_rna of many other GO terms, with 4,409 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SHD-associated GO terms across cancer lineages are Positive regulation of DNA repair, Regulation of DNA repair, and Fatty acid beta-oxidation. Each is linked with SHD in more than 7 cancer types. Because this analysis shows association rather than direction, both SHD-to-partner and partner-to-SHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by SHD-low versus SHD-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHD→partner) and Y-score (partner→SHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of DNA repair →	+0.089	+3.705	<.001	<.001	3	7
SOFT_TISSUE	Regulation of DNA repair →	+0.084	+2.966	<.001	.001	3	7
LARGE_INTESTINE	Fatty acid beta-oxidation →	+0.071	+1.632	<.001	<.001	3	7
BONE	Non-proteinogenic amino acid metabolic process →	+0.113	+0.719	.001	.008	3	7
UPPER_AERODIGESTIVE_TRACT	Detection of bacterial lipoprotein →	-1.161	-0.102	<.001	.002	3	7
SOFT_TISSUE	Sympathetic ganglion development →	-0.189	-1.956	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,409 associations by consensus.

Positive regulation of DNA repair by SHD expression — SOFT_TISSUE

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