SHD

Across TCGA cell cohorts, SHD mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SHD-associated genes across cancer lineages are OR5K2, MAGEB4, and ACSM6. Each is linked with SHD in more than 1 cancer types. Because this analysis shows association rather than direction, both SHD-to-partner and partner-to-SHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5K2 grouped by SHD-low versus SHD-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHD→partner) and Y-score (partner→SHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5K2 →	+0.059	+4.069	<.001	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.019	+3.000	.001	.005	3	1
LARGE_INTESTINE	CCDC195 →	+0.039	+2.882	<.001	.005	3	1
BLOOD_Leukemia	SLC32A1 →	+0.524	+3.901	.002	.006	3	1
BLOOD_Leukemia	MYOCD →	+0.789	+4.108	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR5K2 by SHD expression — SKIN

Explore this box plot interactively →