SHCBP1L

Across TCGA pan-cancer cohorts, SHCBP1L Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SHCBP1L data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SHCBP1L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SHCBP1L expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

LUAD, UCEC, and COAD are the cancer types where SHCBP1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.004	0.751	<.001	24	view →
UCEC	DFS	Median	All	0.964	0.625	.015	24	view →
COAD	OS	Median	All	0.588	0.873	<.001	23	view →
READ	OS	Median	IV	0.111	0.893	<.001	17	view →
SARC	OS	Median	All	0.127	0.860	<.001	9	view →
KIRP	OS	Median	All	0.608	0.903	.039	6	view →
HNSC	DFS	Median	All	0.141	0.626	.008	6	view →
GBM	DFS	Median	All	1.000	0.193	.047	3	view →
SKCM	OS	Median	III,IV	0.216	0.720	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SHCBP1L–LUAD (OS)

Open the LUAD breakdown →