SHC3

Across TCGA patient cohorts, SHC3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHC3-associated genes across cancer lineages are ASNS, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with SHC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SHC3-to-partner and partner-to-SHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SHC3-low versus SHC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC3→partner) and Y-score (partner→SHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.774	+2.815	<.001	.036	3	3
UCEC	FOXO3a_pS318_S321 →	-0.099	-1.430	.014	.022	3	2
UCEC	JNK_pT183_Y185 →	-0.178	-2.584	.001	.001	3	2
UCEC	MEK1 →	+0.302	+1.999	.010	.002	3	2
COAD	p62 Lck ligand →	+0.506	+2.815	.017	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.109	+2.815	.010	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ASNS by SHC3 expression — COAD

Explore this box plot interactively →