SHC3

Across TCGA pan-cancer cohorts, SHC3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SHC3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SHC3 RNA is repressed in tumor relative to normal tissue. In most cancer types SHC3 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KIRP are the cancer types where SHC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.898	<.001	12	view →
LUAD	Male	II,III,IV	−2.061	<.001	9	view →
KIRP	Male	All	−0.875	<.001	9	view →
LUSC	Female	II,III,IV	−2.168	<.001	8	view →
THCA	Female	II,III,IV	+1.047	<.001	7	view →
LIHC	All	II,III,IV	+0.343	<.001	7	view →
BRCA	All	III,IV	−0.866	<.001	6	view →
HNSC	Male	All	−0.371	.008	6	view →
KICH	Female	II,III,IV	−0.909	<.001	5	view →
BLCA	Female	All	−0.650	.011	5	view →
CHOL	All	All	+0.456	.001	3	view →
COAD	All	All	+0.350	.028	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SHC3–KIRC

Open the KIRC breakdown →