SHC3

Across TCGA cell cohorts, SHC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,118 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SHC3-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Positive regulation of cell-substrate junction organization, and Positive regulation of viral process. Each is linked with SHC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SHC3-to-partner and partner-to-SHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by SHC3-low versus SHC3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC3→partner) and Y-score (partner→SHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of cell-substrate adhesion →	+0.081	+0.759	<.001	.008	3	7
OVARY	Positive regulation of cell-substrate junction organization →	+0.087	+0.524	.004	.005	3	7
LUNG_NSCLC_LUAD	Positive regulation of viral process →	+0.050	+0.908	.001	.001	3	7
SKIN	Regulation of cell-substrate junction organization →	+0.078	+0.752	.003	.006	3	6
SKIN	Regulation of cell-matrix adhesion →	+0.066	+0.436	<.001	.009	3	6
SKIN	Regulation of heart rate by chemical signal →	+0.120	+0.475	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,118 associations by consensus.

Regulation of cell-substrate adhesion by SHC3 expression — SKIN

Explore this box plot interactively →