SHC3

Across TCGA cell cohorts, SHC3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHC3-associated genes across cancer lineages are FCN2, OR10K2, and PABPC1L2A. Each is linked with SHC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHC3-to-partner and partner-to-SHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by SHC3-low versus SHC3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHC3→partner) and Y-score (partner→SHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FCN2 →	+0.036	+4.437	<.001	.004	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PZP →	+0.030	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FCN2 by SHC3 expression — SKIN

Explore this box plot interactively →