SHB

Across TCGA pan-cancer cohorts, SHB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SHB data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SHB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SHB expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where SHB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.894	.007	14	view →
CCRCC	DFS	Tertile	IV	0.861	0.137	.024	12	view →
GBM	DFS	Tertile	All	0.226	0.354	.023	6	view →
LSCC	DFS	Quartile	II,III,IV	0.356	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SHB–HNSC (DFS)

Open the HNSC breakdown →