SHB

Across TCGA pan-cancer cohorts, SHB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SHB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SHB RNA is repressed in tumor relative to normal tissue. In most cancer types SHB is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where SHB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.797	<.001	11	view →
COAD	Female	II,III,IV	+1.322	<.001	11	view →
THCA	Male	All	+0.522	<.001	7	view →
BRCA	All	III,IV	+0.959	<.001	6	view →
STAD	All	All	+0.843	<.001	6	view →
UCEC	All	All	+0.674	<.001	6	view →
KIRC	Male	II,III,IV	−0.614	<.001	6	view →
READ	All	All	+1.122	<.001	5	view →
ESCA	All	All	+1.141	.014	2	view →
CHOL	Male	All	+1.018	.014	2	view →
LUSC	Male	II,III,IV	+0.606	.003	2	view →
HNSC	Male	All	+0.496	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SHB–KICH

Open the KICH breakdown →