SHB

Across TCGA patient cohorts, SHB RNA expression is significantly associated with the protein abundance of many other proteins, with 8,583 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SHB-associated proteins across cancer lineages are AKAP13_S790, SHB_S388, and GRHPR. Each is linked with SHB in more than 3 cancer types. Because this analysis shows association rather than direction, both SHB-to-partner and partner-to-SHB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SHB versus AKAP13_S790 in BRCA, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SHB→partner) and Y-score (partner→SHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKAP13_S790 →	+0.981	+0.481	.002	.008	3	4
LSCC	SHB_S388 →	+0.629	+0.672	<.001	<.001	3	4
CCRCC	GRHPR →	+0.324	+0.489	<.001	<.001	3	4
LSCC	NIBAN2 →	+0.285	+0.669	.004	<.001	3	3
GBM	ACO1_T628 →	+0.580	+0.734	<.001	<.001	3	3
OV	C1QB →	+0.514	+0.529	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,583 associations by consensus.

SHB vs AKAP13_S790 — BRCA

Explore this scatter interactively →