SHB

Across TCGA patient cohorts, SHB mutation is significantly associated with the RNA expression of many other genes, with 724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHB-associated genes across cancer lineages are OXSM, GPATCH11, and NCAPH2. Each is linked with SHB in more than 1 cancer types. Because this analysis shows association rather than direction, both SHB-to-partner and partner-to-SHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXSM grouped by SHB-low versus SHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHB→partner) and Y-score (partner→SHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OXSM →	+0.403	+2.379	<.001	.003	3	2
UCEC	GPATCH11 →	+0.516	+3.743	<.001	<.001	3	2
UCEC	NCAPH2 →	+0.455	+3.353	.002	.005	3	2
UCEC	NUDC →	+0.499	+2.523	.001	.001	3	2
HNSC	GAGE2E →	+0.357	+5.608	<.001	.002	3	2
HNSC	RNA5SP19 →	+0.302	+5.008	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 724 associations by consensus.

OXSM by SHB expression — UCEC

Explore this box plot interactively →