SHB

Across TCGA patient cohorts, SHB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHB-associated genes across cancer lineages are eIF4E, Ku80, and MEK1. Each is linked with SHB in more than 1 cancer types. Because this analysis shows association rather than direction, both SHB-to-partner and partner-to-SHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SHB-low versus SHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHB→partner) and Y-score (partner→SHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.192	+2.115	.037	.019	3	1
UCEC	Ku80 →	+0.242	+2.128	.018	.010	3	1
UCEC	MEK1 →	+0.443	+3.321	.005	.010	3	1
UCEC	SETD2 →	-0.189	-2.115	.047	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.536	+2.189	.038	.034	3	1
UCEC	Cyclin-B1 →	+0.494	+2.115	.044	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eIF4E by SHB expression — UCEC

Explore this box plot interactively →