SHB

Across TCGA cell cohorts, SHB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,400 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SHB-associated GO terms across cancer lineages are Response to oscillatory fluid shear stress, Cellular response to oscillatory fluid shear stress, and Vascular endothelial cell response to oscillatory fluid shear stress. Each is linked with SHB in more than 10 cancer types. Because this analysis shows association rather than direction, both SHB-to-partner and partner-to-SHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to oscillatory fluid shear stress grouped by SHB-low versus SHB-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SHB→partner) and Y-score (partner→SHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Response to oscillatory fluid shear stress →	+0.148	+1.191	<.001	<.001	3	11
CNS	Cellular response to oscillatory fluid shear stress →	+0.148	+1.191	<.001	<.001	3	11
CNS	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.148	+1.191	<.001	<.001	3	11
BLOOD_Lymphoma	SMAD protein signal transduction →	+0.106	+1.561	<.001	<.001	3	11
SOFT_TISSUE	Endocytic recycling →	+0.065	+0.997	<.001	.001	3	11
BONE	Latent virus replication →	+0.204	+1.400	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,400 associations by consensus.

Response to oscillatory fluid shear stress by SHB expression — CNS

Explore this box plot interactively →