SHB

Across TCGA cell cohorts, SHB mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SHB-associated genes across cancer lineages are GML, MCHR2, and CCT8L2. Each is linked with SHB in more than 1 cancer types. Because this analysis shows association rather than direction, both SHB-to-partner and partner-to-SHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by SHB-low versus SHB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHB→partner) and Y-score (partner→SHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.088	+4.152	<.001	.009	3	1
BLOOD_Leukemia	MCHR2 →	+0.034	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.087	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1
SKIN	GGTLC2 →	+0.022	+3.103	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

GML by SHB expression — BLOOD_Leukemia

Explore this box plot interactively →