SHB

Across TCGA cell cohorts, SHB mutation is significantly associated with the mutation status of many other genes, with 3,614 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SHB-associated genes across cancer lineages are ZNF337, COL6A5, and FRYL. Each is linked with SHB in more than 3 cancer types. Because this analysis shows association rather than direction, both SHB-to-partner and partner-to-SHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF337 grouped by SHB-low versus SHB-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHB→partner) and Y-score (partner→SHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF337 →	+4.614	+4.614	.006	.006	1	4
CNS	COL6A5 →	+2.877	+4.360	.006	.006	1	4
LARGE_INTESTINE	FRYL →	+1.781	+3.602	.006	.006	1	4
CNS	ACIN1 →	+4.614	+4.614	.006	.006	1	4
SKIN	PHRF1 →	+2.532	+3.078	.005	.005	1	4
BLOOD_Leukemia	MMP25 →	+3.560	+5.209	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,614 associations by consensus.

ZNF337 by SHB expression — CNS

Explore this box plot interactively →